Description

1H-Pyrazole-1-Carbonyl Chloride, 4-Chloro- (9Ci) is a versatile and highly reactive organic intermediate, primarily valued for its role as a key building block in advanced chemical synthesis. Its core value proposition lies in enabling the efficient introduction of the 4-chloropyrazole moiety into target molecules, a critical step in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the pyrazole core provides essential biological activity.
• Chemical Research & Development: Serves as a key reagent in organic synthesis for constructing complex heterocyclic compounds in academic and industrial R&D settings.
• Material Science Precursor: Employed in the synthesis of functional polymers and advanced materials with specific electronic or photophysical properties.
• Ligand Synthesis for Catalysis: Used to prepare specialized pyrazole-based ligands for transition metal catalysis.

Basic Information

Product Name	1H-Pyrazole-1-Carbonyl Chloride, 4-Chloro- (9Ci)
CAS No.	67514-71-0
Molecular Formula	C4H2Cl2N2O
Molecular Weight	164.98 g/mol
Synonyms	4-Chloro-1H-pyrazole-1-carbonyl chloride; 4-Chloropyrazole-1-carbonyl chloride; 1-Carbonylchloride-4-chloropyrazole; 4-Chloro-1-pyrazolecarbonyl chloride; 4-Chloro-1H-pyrazole-1-carboxylic acid chloride; 4-Chloropyrazole-1-carboxylic acid chloride; 67514-71-0 (CAS Registry)
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-1-Carbonyl Chloride, 4-Chloro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP principles where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.