Description

5-Mercurideoxyuridine Triphosphate is a modified nucleotide triphosphate analog, specifically incorporating a mercury atom at the 5-position of the deoxyuridine base. This compound is of significant value in biochemical research and molecular biology for its role as a heavy-atom labeled substrate, enabling specialized analytical and structural studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers working on nucleic acid metabolism, enzyme kinetics, and X-ray crystallography techniques.

Application

• Biochemical Research: Used as a heavy-atom labeled substrate for studying DNA and RNA polymerase mechanisms and kinetics.
• Structural Biology: Acts as a derivative for phase determination in X-ray crystallography of nucleic acid-protein complexes.
• Enzymology Studies: Employed to investigate the specificity and inhibition of thymidylate synthase and related enzymes.
• Nucleic Acid Probe Development: Serves as a precursor for creating mercury-labeled probes for specialized detection assays.
• Antiviral & Anticancer Research: Investigated for its potential as a modified nucleoside analog in therapeutic agent development.
• Metabolic Pathway Analysis: Utilized in tracing and understanding the incorporation of modified nucleotides into nucleic acids.

Basic Information

Product Name	5-Mercurideoxyuridine Triphosphate
CAS No.	67508-92-3
Molecular Formula	C10H15HgN2O14P3
Molecular Weight	Contact for details
Synonyms	5-Hg-dUTP; 5-Mercuri-2'-deoxyuridine-5'-triphosphate; Mercury-dUTP; 5-(Mercuri)-2'-deoxyuridine triphosphate; 5-Mercurated deoxyuridine triphosphate; dUTP-Hg; 5-Hg-dUridine triphosphate
EINECS	Contact for details

Quality Control

Our 5-Mercurideoxyuridine Triphosphate is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and verification of structure by spectroscopic methods. We provide a Certificate of Analysis (COA) with each shipment, detailing batch-specific results for purity, identity, and heavy metal content to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic and light-sensitive nature, the product should be handled under inert atmosphere or dry conditions when opening, and aliquoted to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Mercury Content	Assay by ICP-MS or titration
Water Content (KF)	≤ 2.0%
Solubility	Soluble in aqueous buffer systems

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.