Description

(14β,17R)-3β,14,21-Trihydroxy-5β-Pregnan-20-One 3-Acetate 21-Chloroacetate is a high-purity steroid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its precise stereochemistry and functional groups make it a critical building block for researchers and manufacturers developing novel therapeutic agents. This compound is primarily required by the pharmaceutical and biotechnology industries for the research and production of steroidal drugs and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex steroidal APIs, including corticosteroids and other hormone-based therapies.
• Research & Development: Used in medicinal chemistry for the discovery and structure-activity relationship (SAR) studies of new drug candidates targeting inflammatory and hormonal pathways.
• Process Chemistry: Serves as a standardized starting material or intermediate for scaling up production processes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in academic and industrial research to study steroid metabolism, receptor binding, and enzymatic transformations.

Basic Information

Product Name	(14β,17R)-3β,14,21-Trihydroxy-5β-Pregnan-20-One 3-Acetate 21-Chloroacetate
CAS No.	67462-33-3
Molecular Formula	C25H37ClO6
Molecular Weight	469.01 g/mol
Synonyms	21-Chloroacetoxy-14α,17α-pregnan-3β,14-diol-20-one 3-acetate; 3β,14,21-Trihydroxy-5β-pregnan-20-one 3-acetate 21-chloroacetate; (14β,17R)-Pregnan-20-one derivative; 5β-Pregnane-3β,14,21-triol-20-one 3-acetate 21-chloroacetate; Steroid intermediate 67462-33-3; 21-Chloroacetate of 3β,14-dihydroxy-14α,17α-pregnan-20-one 3-acetate
EINECS	Contact for details

Quality Control

Our (14β,17R)-3β,14,21-Trihydroxy-5β-Pregnan-20-One 3-Acetate 21-Chloroacetate is produced and tested to meet the stringent requirements of pharmaceutical R&D and manufacturing. We employ rigorous analytical protocols including HPLC, NMR, and MS to ensure identity, purity, and consistency across all batches. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.