Description

Adenosine, 5''-[(3-Aminopropyl)Methylsulfonio]-5''-Deoxy-, Sulfate (Salt),Sulfate (Salt) (1:1:1) is a chemically modified adenosine derivative, also known as S-Adenosyl-L-methionine (SAMe) analog, with significant biochemical importance. This compound serves as a critical methyl group donor and regulator in numerous enzymatic processes, making it a valuable high-purity biochemical reagent and research intermediate. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on epigenetics, metabolic studies, and advanced therapeutic development.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of novel therapeutics targeting methylation-related pathways, including potential treatments for liver disorders, depression, and osteoarthritis.
• Biochemical Research: Essential reagent for studying enzymatic transmethylation, transsulfuration, and aminopropylation reactions in vitro.
• Epigenetics Studies: Used as a substrate or inhibitor in research on DNA, RNA, and protein methylation, crucial for understanding gene expression regulation.
• Diagnostic Kit Manufacturing: Serves as a critical raw material in the production of enzymatic assay kits for clinical diagnostics and research.
• Nutraceutical & Cosmetic Ingredient Synthesis: Intermediate for the development of high-value active ingredients in premium nutraceutical and cosmeceutical formulations.
• Process Development & Scale-up: Used by process chemists for developing and optimizing scalable synthetic routes for SAMe and related compounds.

Basic Information

Product Name	Adenosine, 5''-[(3-Aminopropyl)Methylsulfonio]-5''-Deoxy-, Sulfate (Salt),Sulfate (Salt) (1:1:1)
CAS No.	67380-81-8
Molecular Formula	C14H23N6O4S+ • 2HSO4-
Molecular Weight	566.56 g/mol
Synonyms	S-Adenosylmethionine Sulfate Salt; SAMe Sulfate; AdoMet Sulfate; (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Sulfate; 5'-Deoxy-5'-(3-aminopropylmethylsulfonio)adenosine Sulfate; S-Adenosyl-L-methionine Disulfate; SAM-e; L-Methionine, S-adenosyl-, sulfate (1:2)
EINECS	Contact for details

Quality Control

Our production of this biochemical intermediate adheres to stringent Good Manufacturing Practice (GMP) principles for non-API intermediates. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For extended storage under inert atmosphere, contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.