Description

5'-Chloro-5'-Deoxy-9-Deazaadenosine is a chemically modified nucleoside analog that serves as a critical building block and research tool in medicinal chemistry. Its unique structure, featuring a chloro-deoxy modification and a deaza alteration of the purine ring, makes it valuable for probing enzyme mechanisms and developing novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D teams and academic researchers focused on nucleoside metabolism, antiviral drug discovery, and the synthesis of targeted molecular probes.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the activity and mechanism of nucleoside kinases and other metabolic enzymes.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Probe Synthesis: Foundation for creating labeled (e.g., fluorescent, radioactive) compounds for cellular uptake and localization studies.
• Academic Research: Employed in university and institutional labs for fundamental studies in chemical biology and nucleotide chemistry.

Basic Information

Product Name	5'-Chloro-5'-Deoxy-9-Deazaadenosine
CAS No.	67377-77-9
Molecular Formula	C11H13ClN4O3
Molecular Weight	284.70 g/mol
Synonyms	9-Deazaadenosine, 5'-chloro-5'-deoxy-; 5'-Chloro-5'-deoxy-9-deazaadenosine; 4-Amino-1-((2R,3S,5R)-3-chloro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[3,2-d]pyrimidine; 9-Deaza-5'-chloro-5'-deoxyadenosine; 5'-Chloro-5'-deoxy-9-deaza-adenosine; 1H-Pyrrolo[3,2-d]pyrimidin-4-amine, 1-[(2R,3S,5R)-3-chloro-5-(hydroxymethyl)tetrahydro-2-furanyl]-
EINECS	Contact for details

Quality Control

Our 5'-Chloro-5'-Deoxy-9-Deazaadenosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.