Description

1H-Indole-3-Carbonyl Chloride, 2,3-Dihydro-1-Methyl-2-Oxo- (9Ci) CAS NO 67342-11-4 is a specialized heterocyclic building block and reactive intermediate of significant interest in advanced organic synthesis. Its core value lies in the highly versatile acid chloride functional group, enabling efficient amide bond formation and other nucleophilic substitution reactions under controlled conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key precursor for the synthesis of novel indole-based active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides with indole-based active structures.
• Peptide Mimetics & Conjugation: Facilitates the creation of peptide-like molecules and the conjugation of indole motifs to larger biomolecules or polymers.
• Material Science Research: Employed in the development of advanced organic materials, such as dyes, pigments, and functional polymers with specific electronic properties.
• Chemical Biology Probes: Serves as a precursor for synthesizing molecular probes used to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, high-value specialty chemicals for clients.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride, 2,3-Dihydro-1-Methyl-2-Oxo- (9Ci)
CAS No.	67342-11-4
Molecular Formula	C11H10ClNO2
Molecular Weight	223.66 g/mol
Synonyms	1-Methyl-2-oxo-2,3-dihydro-1H-indole-3-carbonyl chloride; 1-Methyl-2-oxindole-3-carbonyl chloride; 2,3-Dihydro-1-methyl-2-oxo-1H-indole-3-carbonyl chloride; 3-(Chlorocarbonyl)-1-methyl-2-oxindole; 1-Methylisatin-3-carbonyl chloride; 1-Methyl-2,3-dioxoindoline-3-carbonyl chloride (tautomer); Oxindole-3-carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carbonyl Chloride, 2,3-Dihydro-1-Methyl-2-Oxo- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.