Description

5-Methyl-4-Isoxazolecarbonyl Chloride is a highly reactive acid chloride derivative of an isoxazole heterocycle, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 5-methyl-4-isoxazolecarbonyl moiety into target molecules, enabling the construction of complex pharmacophores. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting the central nervous system or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole ring.
• Peptide Mimetics & Bioconjugation: Facilitates the acylation of amines in amino acids or peptides to create isoxazole-containing peptide analogs or labeling reagents.
• Material Science Research: Employed in the synthesis of specialized polymers or ligands with tailored electronic or binding properties.
• Chemical Biology Probes: Acts as a reagent for modifying proteins or other biomolecules to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	5-Methyl-4-Isoxazolecarbonyl Chloride
CAS No.	67305-24-2
Molecular Formula	C5H4ClNO2
Molecular Weight	145.55 g/mol
Synonyms	4-Isoxazolecarbonyl chloride, 5-methyl-; 5-Methylisoxazole-4-carbonyl chloride; 5-Methyl-4-isoxazolecarboxylic acid chloride; 5-Methyl-1,2-oxazole-4-carbonyl chloride; 4-Carboxy-5-methylisoxazole chloride; 67305-24-2; 5-Methyl-4-isoxazolylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-4-Isoxazolecarbonyl Chloride is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.