Description

Fenoldopam CAS NO 67227-56-9 is a synthetic benzazepine derivative and a potent, selective dopamine D1-like receptor agonist. This compound is of significant pharmaceutical importance due to its rapid-acting vasodilatory effects, primarily on renal and mesenteric arteries. It is a critical intermediate and active pharmaceutical ingredient (API) for the formulation of injectable solutions used in clinical settings to manage acute hypertensive emergencies and to improve renal function during certain medical procedures. Pharmaceutical manufacturers and advanced research organizations engaged in cardiovascular drug development are the primary users of this high-purity compound.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key bioactive component in formulated injectable drugs for hospital use.
• Hypertension Management: Serves as the core agent in medications designed for the short-term, intravenous control of severe hypertension in hospitalized patients.
• Renal Protection: Used in pharmacological strategies aimed at inducing renal vasodilation to improve blood flow and function in critical care.
• Pharmaceutical Research & Development: A vital reference standard and building block in preclinical and clinical studies for novel cardiovascular therapies.
• Chemical Synthesis: Acts as a sophisticated intermediate for the synthesis of more complex dopamine receptor-targeting analogs and metabolites.
• Analytical Standard: Employed as a high-purity calibrant in quality control laboratories for HPLC, LC-MS, and other analytical methods to ensure drug product consistency.

Basic Information

Product Name	Fenoldopam
CAS No.	67227-56-9
Molecular Formula	C16H16ClNO3
Molecular Weight	305.76 g/mol
Synonyms	Fenoldopam Mesylate (common salt form); SKF-82526; 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol; Corlopam (brand name); DA-1 receptor agonist; (6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-benzazepine-7,8-diol)
EINECS	Contact for details

Quality Control

Our Fenoldopam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for key parameters such as assay (by HPLC), related substances, residual solvents, and identification (by IR and MS). We support compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.