Description

Butoconazole is a potent synthetic imidazole derivative widely recognized for its exceptional antifungal properties. This active pharmaceutical ingredient (API) is crucial for developing effective therapeutic formulations targeting fungal infections. It is primarily sought after by pharmaceutical manufacturers and research institutions in the global healthcare sector for the production of topical antifungal medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter (OTC) topical antifungal creams, ointments, and suppositories.
• Vaginal Antifungal Formulations: Key component in treatments for vulvovaginal candidiasis (yeast infections).
• Dermatological Products: Used in creams for treating cutaneous fungal infections such as tinea corporis (ringworm), tinea cruris (jock itch), and tinea pedis (athlete's foot).
• Veterinary Medicine: Incorporated into topical preparations for treating fungal skin conditions in animals.
• Research & Development: Serves as a reference standard and a key intermediate in biochemical research for studying antifungal mechanisms and developing new azole derivatives.

Basic Information

Product Name	Butoconazole
CAS No.	67085-13-6
Molecular Formula	C19H17Cl3N2S
Molecular Weight	411.78 g/mol
Synonyms	Butoconazole Nitrate; 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; (±)-Butoconazole; RS-35887; Femstat (trade name); Gynazole-1 (trade name); (RS)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]imidazole
EINECS	266-559-6

Quality Control

Our Butoconazole is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, and impurity profile checks against relevant pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Microbial Limit	Conforms to USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.