Description

6 α-Hydroxy(Allo)Tetrahydrocortisol is a key synthetic intermediate and reference standard in the production and analysis of steroid-based pharmaceuticals. This compound is valued for its role in the research and development of corticosteroids and other therapeutic agents targeting inflammatory and hormonal pathways. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in advanced steroid chemistry, drug discovery, and quality control processes.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent corticosteroid drugs and their analogs.
• Reference Standard: Used as a high-purity standard in analytical methods (e.g., HPLC, LC-MS) for the identification and quantification of steroid compounds in active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Research: Employed in studies investigating the metabolic pathways and pharmacokinetics of cortisol and related steroid hormones.
• Biochemical Research: Serves as a tool compound in enzymatic studies and receptor binding assays to understand steroid hormone action and regulation.
• Process Development: Used in the development and optimization of synthetic routes for steroid manufacturing within GMP environments.

Basic Information

Product Name	6 α-Hydroxy(Allo)Tetrahydrocortisol
CAS No.	67010-78-0
Molecular Formula	C21H34O6
Molecular Weight	382.50 g/mol
Synonyms	6α-Hydroxyallotetrahydrocortisol; (6α,11β,17α)-6,11,17,21-Tetrahydroxypregnane-3,20-dione; 6α-Hydroxy-5β-pregnane-3,11,17,20,21-pentol; Allotetrahydrocortisol 6α-ol; 3α,17α,21-Trihydroxy-5β-pregnane-11,20-dione 6α-ol; 6α-Hydroxy-3α,17α,21-trihydroxy-5β-pregnan-20-one; A reference standard for steroid analysis.
EINECS	Contact for details

Quality Control

Our 6 α-Hydroxy(Allo)Tetrahydrocortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.