Description

Halobetasol Propionate is a synthetic corticosteroid belonging to the class of very-high-potency topical glucocorticoids. It is a critical active pharmaceutical ingredient (API) valued for its potent anti-inflammatory, antipruritic, and vasoconstrictive properties. This compound is primarily utilized by pharmaceutical manufacturers in the development and production of prescription-strength topical formulations, such as creams, ointments, and lotions, for treating severe dermatological conditions.

Application

• Topical Corticosteroid Formulations: Primary API in prescription creams, ointments, gels, and lotions for treating severe skin inflammation.
• Psoriasis Treatment: Key ingredient in medications designed to manage plaque psoriasis and other steroid-responsive dermatoses.
• Eczema and Dermatitis Management: Used in formulations for controlling symptoms of atopic dermatitis, contact dermatitis, and other eczematous disorders.
• Lichen Planus Therapy: Incorporated into treatments for cutaneous lichen planus.
• Research & Development: Serves as a reference standard and building block in pharmaceutical R&D for novel topical anti-inflammatory agents.
• Veterinary Dermatology: Potential use in topical preparations for managing inflammatory skin conditions in animals.

Basic Information

Product Name	Halobetasol Propionate
CAS No.	66852-54-8
Molecular Formula	C25H31ClF2O5
Molecular Weight	485.0 g/mol
Synonyms	Ultravate (Trade Name); (6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; CGP 14458; 21-Chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; Halobetasol 17-propionate
EINECS	266-500-6

Quality Control

Our Halobetasol Propionate is manufactured under strict quality management systems. It is typically supplied to meet USP/EP/ICH guidelines for pharmaceutical active ingredients, ensuring identity, purity, strength, and composition. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing all critical quality attributes. We support our partners with full regulatory documentation and stability data packages as required for drug master files (DMF) and market authorization dossiers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Loss on Drying	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Particle Size	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.