Description

Cytidine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro- is a modified nucleoside triphosphate analog where the 2'-hydroxyl group of the ribose sugar is replaced by a fluorine atom. This structural modification is crucial for its primary role as a building block in the synthesis of modified oligonucleotides, particularly for therapeutic and diagnostic applications. It is an essential raw material for pharmaceutical R&D, specifically in the development of antisense oligonucleotides, siRNA, and aptamers. The product is supplied as a high-purity biochemical reagent to meet the stringent demands of advanced life science research and biopharmaceutical manufacturing.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite precursor for creating therapeutic oligonucleotides that modulate gene expression.
• siRNA and miRNA Research: Used to incorporate stable 2'-fluoro modifications into RNA strands to enhance nuclease resistance and improve in vivo stability.
• Aptamer Development: Enables the production of nuclease-resistant aptamers for diagnostic and therapeutic targeting.
• Structural Biology Studies: A valuable tool for investigating RNA structure, function, and protein-RNA interactions via X-ray crystallography and NMR.
• Diagnostic Probe Manufacturing: Used in the synthesis of labeled probes for sensitive detection assays like qPCR and FISH.
• Vaccine Research: Investigated as a component in mRNA-based vaccine platforms to modulate immunogenicity and stability.

Basic Information

Product Name	Cytidine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro-
CAS No.	66840-03-7
Molecular Formula	C9H15FN3O13P3
Molecular Weight	503.14 g/mol
Synonyms	2'-Deoxy-2'-fluorocytidine-5'-triphosphate; 2'-F-CTP; 2'-Fluoro-CTP; 2'-F-dCTP; 2'-Fluoro-2'-deoxycytidine 5'-triphosphate; 2'-Fluoro-2'-deoxy-CTP; F-dCTP; 2'-F-cytidine triphosphate
EINECS	Contact for details

Quality Control

Our Cytidine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and nucleic acid synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Bioburden	To be specified per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.