Description

Uridine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro- is a modified nucleoside triphosphate analog, specifically a fluorinated derivative of uridine triphosphate (UTP). This compound is a critical building block in oligonucleotide synthesis, enabling the creation of RNA molecules with enhanced stability and specific biological properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications in antisense therapy, RNA interference (RNAi), and diagnostic assay development.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Key monomer for producing therapeutic oligonucleotides designed to target and modulate specific RNA sequences.
• siRNA and RNAi Reagent Production: Used in the solid-phase synthesis of small interfering RNA (siRNA) duplexes for gene silencing research and therapeutic development.
• Diagnostic Probe Development: Incorporated into fluorescently-labeled or modified RNA probes for in situ hybridization (ISH) and other molecular diagnostic techniques.
• Structural Biology Studies: Employed to synthesize modified RNAs for NMR and X-ray crystallography to study RNA structure, function, and protein interactions.
• Vaccine Research: Potential use in the synthesis of modified mRNA constructs for vaccine and therapeutic protein expression platforms.
• Enzymology and Biochemistry: Serves as a substrate or inhibitor for studies involving RNA polymerases, helicases, and other RNA-processing enzymes.

Basic Information

Product Name	Uridine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro-
CAS No.	66840-02-6
Molecular Formula	C9H14FN2O14P3
Molecular Weight	502.13 g/mol
Synonyms	2'-Deoxy-2'-fluorouridine-5'-triphosphate; 2'-F-UTP; 2'-Fluoro-2'-deoxyuridine 5'-triphosphate; 2'-Fluoro-UTP; 5'-UTP, 2'-deoxy-2'-fluoro-; Fluorouridine triphosphate; 1-[(2R,3S,4R,5R)-5-(Fluoromethyl)-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione 5'-(trihydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our Uridine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-2'-Fluoro- is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical and diagnostic applications. Certificates of Analysis (COA) detailing purity, impurity profile, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Triethylammonium Salt Content	Contact for details
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.