Description

m-Peg3-Acid Chloride is a versatile bifunctional PEG linker featuring a carboxylic acid chloride group for efficient acylation reactions. This compound is critical for introducing a hydrophilic polyethylene glycol spacer arm into target molecules, significantly improving their solubility and pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for drug delivery system development, protein modification, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutics.
• Bioconjugation Reagent: Used for PEGylating peptides, proteins, and oligonucleotides to enhance stability and reduce immunogenicity.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of functionalized, biodegradable, or stimuli-responsive polymers.
• Surface Modification: Facilitates the covalent attachment of bioactive molecules to nanoparticles, biosensors, and medical device surfaces.
• Chemical Biology Probes: Enables the synthesis of probes for studying biological processes and interactions.
• Material Science: Used in creating hydrogels and other advanced materials with tailored properties.

Basic Information

Product Name	m-Peg3-Acid Chloride
CAS No.	66722-87-0
Molecular Formula	C9H17ClO4
Molecular Weight	224.68 g/mol
Synonyms	3,6,9-Trioxaundecanedioyl Dichloride; 2,2'-Ethylenedioxydiethyl Chloroformate; PEG3 Diacid Chloride; Bis(2-chloroethoxy)ethoxyacetyl Chloride; mPEG3-acid chloride; Acid-PEG3-acid chloride; 11-Amino-3,6,9-trioxaundecan-1-oic Acid Chloride Derivative; α-Methoxy-ω-chloroformyl-poly(ethylene glycol)
EINECS	Contact for details

Quality Control

Our m-Peg3-Acid Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place (recommended 2-8°C or as specified on the label) under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and incompatible with strong bases, alcohols, and water. Keep the container tightly sealed in a desiccated environment to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.