Description

3,3′,5′-Triiodo-D-Thyronine is a stereoisomer of the endogenous thyroid hormone triiodothyronine (T3). This compound matters as a critical biochemical tool and reference standard for research into thyroid hormone action, metabolism, and receptor binding studies. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic kits for studying hormone pathways and developing analytical methods.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, LC-MS) in drug development and quality control.
• Biochemical Research: Serves as a key reagent in studies of thyroid hormone receptors (TRα and TRβ), investigating mechanisms of action and metabolic pathways.
• Diagnostic Development: Employed in the production and quality assurance of immunoassay kits for the precise measurement of thyroid hormone levels.
• Metabolic Studies: Utilized in cellular and animal models to explore the effects of thyroid hormone isomers on metabolism, growth, and development.
• Chemical Synthesis Intermediate: Acts as a chiral building block or precursor in the synthesis of novel thyroid hormone analogs or labeled compounds for tracer studies.

Basic Information

Product Name	3,3′,5′-Triiodo-D-Thyronine
CAS No.	66701-15-3
Molecular Formula	C15H11I3NO4
Molecular Weight	650.96 g/mol
Synonyms	D-Triiodothyronine; D-T3; D-3,3',5-Triiodothyronine; (R)-3,3',5-Triiodothyronine; (R)-T3; D-Thyronine, 3,3',5-triiodo-; Reverse T3 isomer; D-3,3',5-Triiodo-L-thyronine (common misnomer)
EINECS	Contact for details

Quality Control

Our 3,3′,5′-Triiodo-D-Thyronine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.