Description

2,3-Difluoro-4-Nitroanisole is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a nitro group, which allows for precise manipulation of electronic properties and reactivity in downstream molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro-nitroanisole structure contributes to product efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Liquid Crystal & Dye Intermediate: Employed in the synthesis of fluorinated dyes and liquid crystal compounds for display technologies.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups activate the ring for selective substitution, enabling the introduction of various amines, alkoxides, and other nucleophiles.

Basic Information

Product Name	2,3-Difluoro-4-Nitroanisole
CAS No.	66684-59-1
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1,2-Difluoro-3-methoxy-4-nitrobenzene; 3-Methoxy-1,2-difluoro-4-nitrobenzene; 4-Nitro-2,3-difluoroanisole; Benzene, 1,2-difluoro-3-methoxy-4-nitro-; 2,3-Difluoro-4-nitro-1-methoxybenzene
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Nitroanisole is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as verified by HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.