Description

5-Aza-2'-Deoxycytidine-5'-Monophosphate is a biologically active nucleoside analog and a key intermediate in the synthesis of DNA methyltransferase inhibitors. This compound is critical for epigenetic research and therapeutic development, as it is a phosphorylated derivative of the well-known hypomethylating agent decitabine. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on oncology and epigenetics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of advanced nucleoside-based therapeutics, particularly DNA methyltransferase (DNMT) inhibitors.
• Epigenetics Research: Used as a tool compound in biochemical assays to study DNA methylation patterns, gene silencing, and cellular differentiation.
• Oncology Studies: Employed in preclinical research to investigate mechanisms of action for hypomethylating agents in various cancer cell lines.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled probes or conjugates for diagnostic and research applications.
• Process Development: Used in scaling up and optimizing synthetic routes for the production of related active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control in the manufacturing of related nucleoside drugs.

Basic Information

Product Name	5-Aza-2'-Deoxycytidine-5'-Monophosphate
CAS No.	66642-55-5
Molecular Formula	C9H14N4O7P
Molecular Weight	321.21 g/mol
Synonyms	5-Aza-dCMP; Decitabine-5'-Monophosphate; 5-Aza-2'-deoxycytidine monophosphate; 5-Aza-CdR monophosphate; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one 5'-monophosphate; NSC 264580; 5-Aza-2'-deoxycytidine 5'-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 5-Aza-2'-Deoxycytidine-5'-Monophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with customer requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.