Description

Uridine-5-Oxyacetic Acid Methyl Ester is a chemically modified nucleoside derivative, specifically a methyl ester of uridine substituted at the 5-position. This compound is a crucial building block and key intermediate in the synthesis of more complex nucleoside analogs and oligonucleotides. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic research institutions focused on developing novel therapeutics and molecular probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of modified nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for creating therapeutic and diagnostic oligonucleotides.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to RNA metabolism and modification.
• Probe Development: Enables the creation of labeled nucleosides for fluorescence in situ hybridization (FISH) and other detection techniques.
• Academic Research: Fundamental research tool for studying nucleic acid chemistry, structure, and function.
• API Development: Intermediate in the development of Active Pharmaceutical Ingredients (APIs) for novel drug candidates.

Basic Information

Product Name	Uridine-5-Oxyacetic Acid Methyl Ester
CAS No.	66536-81-0
Molecular Formula	C12H16N2O9
Molecular Weight	332.26 g/mol
Synonyms	5-Carboxymethoxyuridine Methyl Ester; 5-O-Carboxymethyluridine Methyl Ester; Uridine-5'-O-acetic Acid Methyl Ester; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-((methoxycarbonyl)methoxy)pyrimidine-2,4(1H,3H)-dione; 5-(Methoxycarbonylmethoxy)uridine; cmo5U Methyl Ester
EINECS	Contact for details

Quality Control

Our Uridine-5-Oxyacetic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems support development from research to commercial scale, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.