Description

5'-Sulfamoyl-2-Chloroadenosine is a high-purity, modified nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and biochemical tool for exploring nucleotide-based pathways and enzyme inhibition. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel adenosine analog-based drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, phosphorylases, and other nucleotide-processing enzymes.
• Antiviral Drug Discovery: Investigated for its potential role in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Oncology Research: Employed in research targeting purine metabolism and the development of chemotherapeutic agents that disrupt DNA/RNA synthesis.
• Probe Development: Utilized in creating labeled probes or affinity reagents for studying adenosine receptor interactions and signaling pathways.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and process optimization for active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	5'-Sulfamoyl-2-Chloroadenosine
CAS No.	66522-52-9
Molecular Formula	C11H14ClN7O5S
Molecular Weight	391.79 g/mol
Synonyms	2-Chloro-5'-sulfamoyladenosine; 2-Chloroadenosine-5'-sulfonamide; 2-Cl-5'-NH2SO2-Ado; 9-β-D-Ribofuranosyl-2-chloroadenine-5'-sulfonamide; Adenosine, 2-chloro-5'-(aminosulfonyl)-; 5'-Sulfamoyl-2-chloroadenosine; 2-Chloro-5'-O-sulfamoyladenosine
EINECS	Contact for details

Quality Control

Our 5'-Sulfamoyl-2-Chloroadenosine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain product integrity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.