Description

Fosmidomycin is a potent, naturally occurring antibiotic and a specific, non-competitive inhibitor of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) enzyme. This unique mechanism of action makes it a critical research tool and a lead compound for developing novel antimicrobial and antimalarial agents. It is essential for researchers in pharmaceutical development, biochemistry, and microbiology, particularly those investigating isoprenoid biosynthesis pathways and novel treatments for drug-resistant infections.

Application

• Biochemical Research: As a highly specific inhibitor of the DXR enzyme in the non-mevalonate (MEP) pathway for isoprenoid biosynthesis.
• Antimicrobial Development: Serves as a lead compound and molecular scaffold for the design of new antibiotics targeting Gram-negative bacteria.
• Antimalarial Research: Investigated for its activity against Plasmodium falciparum due to its inhibition of the essential MEP pathway in the parasite.
• Plant Science Studies: Used to study isoprenoid production and related metabolic processes in plants and algae.
• Enzyme Inhibition Studies: A standard tool for characterizing DXR enzyme kinetics and structure-activity relationships (SAR).
• Pharmaceutical Intermediates: Potential use in the synthesis of more complex therapeutic agents targeting infectious diseases.

Basic Information

Product Name	Fosmidomycin
CAS No.	66508-53-0
Molecular Formula	C7H16NO7P
Molecular Weight	257.18 g/mol
Synonyms	FR-31564; Phosphonomycin; (3-Formyl-hydroxy-2-oxopropyl)phosphonic acid; (3-(Formyl-hydroxy-2-oxopropyl)phosphonic acid; (3-(N-Hydroxyformamido)-2-oxopropyl)phosphonic acid; Antibiotic FR-31564; Fosmidomycin sodium salt (common salt form)
EINECS	Contact for details

Quality Control

Our Fosmidomycin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.