Description

5-(Trifluoromethyl)-2'-Deoxycytidine is a modified nucleoside analog where a trifluoromethyl group is introduced at the 5-position of the cytosine base. This compound matters for its role as a critical building block in oligonucleotide synthesis, enabling the development of advanced therapeutic and diagnostic agents. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and other nucleic acid-based modalities.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Therapy Development: Used to incorporate stability-enhancing modifications into antisense oligonucleotides for therapeutic applications.
• siRNA and miRNA Research: Employed in the design and synthesis of small interfering RNA (siRNA) and microRNA (miRNA) constructs to modulate gene expression.
• Diagnostic Probe Fabrication: Integral to creating labeled probes for molecular diagnostics, including FISH and PCR-based assays.
• Structural Biology Studies: Utilized to investigate the structure-function relationships of nucleic acids and their interactions with proteins.
• Medicinal Chemistry: Serves as a scaffold for the discovery and optimization of novel nucleoside-based antiviral and anticancer agents.

Basic Information

Product Name	5-(Trifluoromethyl)-2'-Deoxycytidine
CAS No.	66384-66-5
Molecular Formula	C10H12F3N3O4
Molecular Weight	295.21 g/mol
Synonyms	5-Trifluoromethyl-2'-deoxycytidine; 5-CF3-dC; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione; 5-(Trifluoromethyl)cytosine deoxyriboside; 2'-Deoxy-5-(trifluoromethyl)cytidine; dC(CF3)
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-2'-Deoxycytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.