Description

5'-Deoxy-5-Fluoro-2',3'-o-Isopropylidene-D-Cytidine is a key fluorinated nucleoside derivative, serving as a crucial advanced intermediate in the synthesis of novel antiviral and anticancer agents. Its value lies in its protected ribose moiety and specific fluorination, which are essential for modulating the biological activity and metabolic stability of the final active pharmaceutical ingredients (APIs). This high-purity building block is primarily needed by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated cytidine analogs with potential antiviral and anticancer activities.
• Antiviral Drug Research: Used in the research and development of novel nucleoside reverse transcriptase inhibitors and other antiviral compounds.
• Oncology Drug Discovery: Serves as a precursor in creating fluoropyrimidine-based chemotherapeutic agents that target DNA/RNA synthesis.
• Biochemical Research: Employed in studies investigating nucleoside metabolism, enzyme mechanisms, and structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Used by CDMOs for the process development and cGMP manufacturing of complex active pharmaceutical ingredients (APIs).
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5'-Deoxy-5-Fluoro-2',3'-o-Isopropylidene-D-Cytidine
CAS No.	66335-37-3
Molecular Formula	C₁₂H₁₆FN₃O₄
Molecular Weight	285.27 g/mol
Synonyms	5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine; 5-Fluoro-2',3'-O-isopropylidene-5'-deoxycytidine; 5'-Deoxy-5-fluoro-2',3'-O-(1-methylethylidene)-D-cytidine; 5-Fluoro-5'-deoxy-2',3'-O-isopropylidenecytidine; D-Cytidine, 5'-deoxy-5-fluoro-2',3'-O-(1-methylethylidene)-; 5-FdCyd(isop); Fluorinated Isopropylidene Cytidine Intermediate
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5-Fluoro-2',3'-o-Isopropylidene-D-Cytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.