Description

4-(Trifluoromethyl)Phenyl Chlorothioformate is a specialized organosulfur reagent featuring a reactive chlorothioformate group and a trifluoromethylphenyl moiety. This compound matters as a versatile building block for introducing the S-COCl functional group, which is valuable for synthesizing thioesters, thiocarbamates, and other sulfur-containing derivatives. It is needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfur-based functional groups or trifluoromethyl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the chlorothioformate group enables efficient derivatization.
• Polymer & Material Science: Serves as a monomer or modifying agent for creating specialty polymers, coatings, and materials with specific surface properties.
• Chemical Research & Development: A valuable reagent in organic synthesis for constructing thioester and thiocarbamate linkages under mild conditions.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands and catalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	4-(Trifluoromethyl)Phenyl Chlorothioformate
CAS No.	66300-15-0
Molecular Formula	C8H4ClF3OS
Molecular Weight	240.63 g/mol
Synonyms	p-(Trifluoromethyl)phenyl chlorothioformate; 4-(Trifluoromethyl)benzenecarbonochloridothioate; 4-Trifluoromethylphenyl chlorothioformate; α,α,α-Trifluoro-p-tolyl chlorothioformate; Chlorothioformic acid O-(4-trifluoromethylphenyl) ester; 1-(Chlorothioformyloxy)-4-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Phenyl Chlorothioformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.