Description

2',3',4',5'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone building block, identified by CAS NO 66286-21-3. This compound is valued for its unique electronic and steric properties imparted by the tetrafluoro substitution pattern, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides with enhanced activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting technologies.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with improved chemical resistance and thermal stability.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis.
• Material Science Research: Employed in the development of novel fluorinated coatings and surface modifiers.

Basic Information

Product Name	2',3',4',5'-Tetrafluoroacetophenone
CAS No.	66286-21-3
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	1-(2,3,4,5-Tetrafluorophenyl)ethanone; 2,3,4,5-Tetrafluoroacetophenone; Tetrafluoroacetophenone; α,2,3,4-Tetrafluoroacetophenone; 2,3,4,5-Tetrafluorophenyl methyl ketone; Ethanone, 1-(2,3,4,5-tetrafluorophenyl)-; 2',3',4',5'-Tetrafluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2',3',4',5'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.