Description

1-(4-Fluorophenyl)Cyclopropan-1-Ol CAS NO 66267-05-8 is a high-purity fluorinated cyclopropanol derivative, serving as a versatile and critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a fluorinated aromatic ring and a strained cyclopropane ring bearing a hydroxyl group, makes it invaluable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorophenyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals, where the cyclopropane unit can impart unique rigidity and optical properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	1-(4-Fluorophenyl)Cyclopropan-1-Ol
CAS No.	66267-05-8
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(4-Fluorophenyl)cyclopropanol; (4-Fluorophenyl)cyclopropylmethanol; α-(4-Fluorophenyl)cyclopropanemethanol; 4-Fluoro-α-(hydroxymethyl)benzenecarbene; 1-(p-Fluorophenyl)cyclopropan-1-ol; p-Fluorophenylcyclopropanol; 66267-05-8; FCPO
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)Cyclopropan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Enantiomerically Enriched)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.