Description

3-(Trimethylsilyl)Propioloyl Chloride is a highly reactive organosilicon building block featuring both a silyl-protected acetylene and an acid chloride functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, enabling efficient carbon-carbon bond formation and the introduction of silicon moieties. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction for active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring acetylene or silicon-containing scaffolds.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and plant growth regulators that benefit from silicon's bioactivity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, silicones, and advanced organic-inorganic hybrid materials.
• Organic Synthesis Reagent: Employed in Sonogashira coupling and other cross-coupling reactions to introduce alkynyl groups into target molecules under mild conditions.
• Liquid Crystal & OLED Materials: A precursor for synthesizing conjugated molecules and charge-transport materials used in display and lighting technologies.
• Surface Modification: Used to derivatize surfaces (e.g., silica, glass) with alkynyl groups for further functionalization via click chemistry.

Basic Information

Product Name	3-(Trimethylsilyl)Propioloyl Chloride
CAS No.	66224-70-2
Molecular Formula	C6H9ClOSi
Molecular Weight	160.67 g/mol
Synonyms	Propioloyl chloride, 3-(trimethylsilyl)-; Trimethylsilylpropiolic acid chloride; 3-(Trimethylsilyl)propynoyl chloride; TMS-propioloyl chloride; (Trimethylsilyl)ethynoyl chloride; 2-Trimethylsilylethynoyl chloride; 3-Trimethylsilylpropiolic acid chloride
EINECS	Contact for details

Quality Control

Our production of 3-(Trimethylsilyl)Propioloyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.