Description

Arabinosylthymine 5'-Triphosphate is a modified nucleoside triphosphate analog, a critical building block for nucleic acid research and development. This compound is essential for studying DNA/RNA synthesis, enzyme mechanisms, and as a potential antiviral agent. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in molecular biology and therapeutic discovery.

Application

• Enzymatic Substrate Studies: Used as a substrate or inhibitor for DNA polymerases, reverse transcriptases, and other nucleic acid-processing enzymes to investigate catalytic mechanisms and fidelity.
• Antiviral Research: Serves as a key compound in the development and evaluation of nucleoside analog-based antiviral therapies, particularly against viral polymerases.
• Probe Synthesis: Incorporated into oligonucleotides via enzymatic synthesis to create labeled probes for hybridization, sequencing, or diagnostic assays.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify novel enzyme inhibitors or modulators for drug discovery.
• Metabolic Pathway Analysis: Used to trace and study the incorporation of modified nucleotides into nucleic acids within cellular systems.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of enzyme-substrate complexes.

Basic Information

Product Name	Arabinosylthymine 5'-Triphosphate
CAS No.	66097-68-5
Molecular Formula	C15H23N3O16P3
Molecular Weight	594.26 g/mol
Synonyms	1-β-D-Arabinofuranosylthymine 5'-triphosphate; araTTP; Arabinofuranosylthymine triphosphate; 5'-Triphosphoric acid, 1-(2-deoxy-β-D-arabinofuranosyl)thymine; Thymine arabinoside triphosphate; β-D-Arabinothymidine 5'-triphosphate; 1-(β-D-Arabinofuranosyl)thymine 5'-triphosphate
EINECS	Contact for details

Quality Control

Our Arabinosylthymine 5'-Triphosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.