Description

Guanosine 2',3',5'-Tribenzoate CAS NO 66048-53-1 is a key protected nucleoside derivative, where the ribose hydroxyl groups are selectively benzoylated. This chemical intermediate is critical for the controlled synthesis of oligonucleotides and modified nucleosides, enabling precise research and development in advanced fields. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleic acid chemistry, antiviral drug discovery, and the development of novel molecular probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of DNA/RNA sequences for research and therapeutic applications.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid structure, and as a precursor for fluorescently labeled nucleotides.
• Prodrug Development: Acts as a starting material for creating prodrugs with enhanced bioavailability and targeted delivery.
• Academic & Industrial R&D: Essential for exploratory chemistry in universities and corporate labs developing novel nucleic acid-based technologies.

Basic Information

Product Name	Guanosine 2',3',5'-Tribenzoate
CAS No.	66048-53-1
Molecular Formula	C33H27N5O8
Molecular Weight	621.60 g/mol
Synonyms	2',3',5'-Tri-O-benzoylguanosine; Guanosine 2',3',5'-tribenzoate; 9-[(2R,3R,4R,5R)-3,4-Bis(benzoyloxy)-5-(benzoyloxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 2',3',5'-Tri-O-benzoyl-guanosine; Tribenzoyl guanosine; Guanosine tribenzoate
EINECS	Contact for details

Quality Control

Our Guanosine 2',3',5'-Tribenzoate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.