Description

1H-Benzimidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- (9Ci) is a reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the benzimidazolone pharmacophore, a privileged scaffold in medicinal chemistry, into target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of benzimidazolone-based drug candidates, including kinase inhibitors, receptor antagonists, and enzyme modulators.
• Agrochemical Synthesis: Used in creating novel fungicides, herbicides, and plant growth regulators that leverage the benzimidazole core for bioactivity.
• Material Science Research: Building block for constructing functional organic molecules and polymers with specific electronic or binding properties.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes and affinity tags for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for clinical trials and commercial APIs.

Basic Information

Product Name	1H-Benzimidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- (9Ci)
CAS No.	65657-53-6
Molecular Formula	C8H5ClN2O2
Molecular Weight	196.59 g/mol
Synonyms	2-Oxo-2,3-dihydro-1H-benzimidazole-1-carbonyl chloride; 1H-Benzimidazole-1-carbonyl chloride, 2,3-dihydro-2-oxo-; 2-Oxobenzimidazoline-1-carbonyl chloride; 1-Carboxybenzimidazolone chloride; Benzimidazolone-1-carbonyl chloride; 1-Chlorocarbonylbenzimidazolone; 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Benzimidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- (9Ci) adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.