Description

Naftifine Hydrochloride CAS NO 65473-14-5 is a synthetic allylamine antifungal agent, widely recognized for its potent fungicidal and fungistatic activity. Its primary commercial value lies in its effectiveness against dermatophytes and other fungi, making it a critical active pharmaceutical ingredient (API). This compound is essential for manufacturers in the pharmaceutical industry developing topical antifungal creams, gels, and sprays for the treatment of conditions like athlete's foot, jock itch, and ringworm.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical antifungal formulations.
• Key component in prescription and over-the-counter (OTC) creams and gels for dermatophytosis.
• Used in the formulation of antifungal powders and sprays.
• Intermediate in the synthesis of more complex antifungal pharmaceutical compounds.
• Active agent in veterinary antifungal products.
• Reference standard in analytical laboratories for quality control and research.

Basic Information

Product Name	Naftifine Hydrochloride
CAS No.	65473-14-5
Molecular Formula	C21H21N·HCl
Molecular Weight	323.86 g/mol (as hydrochloride)
Synonyms	Naftifine HCl; (E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine Hydrochloride; (E)-N-Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine Hydrochloride; Naftin (trade name); Exoderil (trade name); (2E)-N-Methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine Hydrochloride; Allylamine antifungal; AW 105-843
EINECS	Contact for details

Quality Control

Our Naftifine Hydrochloride is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality assurance protocols are designed to ensure batch-to-batch consistency, identity, purity, and strength. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests including identification, assay, related substances, and residual solvents, in alignment with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.