Description

Naftifine CAS NO 65472-88-0 is a synthetic allylamine derivative that functions as a potent antifungal agent. Its primary value lies in its broad-spectrum fungicidal and fungistatic activity, particularly against dermatophytes and other pathogenic fungi. This makes it a critical active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical and personal care industries, specifically for developing topical antifungal treatments.

Application

• Pharmaceutical API: Primary use as the active ingredient in topical creams, gels, and solutions for treating fungal skin infections such as athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis).
• Dermatological Preparations: Formulated into medicated powders, sprays, and ointments for over-the-counter (OTC) and prescription antifungal products.
• Veterinary Medicine: Used in topical antifungal formulations for treating dermatophyte infections in companion animals and livestock.
• Research & Development: Serves as a reference standard and key intermediate in biochemical research focused on antifungal mechanisms of action and the development of new therapeutic agents.
• Cosmeceutical Products: Incorporated into specialized foot care and hygiene products designed for antifungal protection.

Basic Information

Product Name	Naftifine
CAS No.	65472-88-0
Molecular Formula	C21H21N
Molecular Weight	287.40 g/mol
Synonyms	(E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine; (2E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine; Naftifine Hydrochloride (salt form); AW 105-843; Fetimin; Exoderil (brand name); N-Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine; (E)-N-Methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
EINECS	265-798-9

Quality Control

Our Naftifine is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support compliance with ICH guidelines for stability and impurity qualification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.