Description

2'-Bromo-2'-Deoxyadenosine is a modified nucleoside analog where a bromine atom is introduced at the 2' position of the deoxyribose sugar, serving as a crucial building block and intermediate in synthetic organic chemistry. This modification is strategically important for the development of nucleotide-based therapeutics and for probing biochemical pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, oligonucleotide synthesis, and biochemical research.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for antisense therapy, siRNA, and diagnostic probes.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of DNA polymerases and other nucleic acid-metabolizing enzymes.
• Prodrug Development: Serves as a precursor molecule in the design of prodrugs aimed at improving drug delivery and bioavailability.
• Chemical Biology Tool: Employed to introduce site-specific modifications into nucleic acids for structure-activity relationship (SAR) studies.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2'-Bromo-2'-Deoxyadenosine
CAS No.	65446-56-2
Molecular Formula	C10H12BrN5O3
Molecular Weight	330.14 g/mol
Synonyms	9-(2-Bromo-2-deoxy-β-D-erythro-pentofuranosyl)adenine; 2'-Bromo-2'-deoxyadenosine; 2'-Bromo-2'-deoxy-D-adenosine; 2'-Bromodeoxyadenosine; 2'-Br-dA; Adenosine, 2'-bromo-2'-deoxy-; 2'-Bromo-2'-deoxy-β-D-adenosine; 2'-Bromo-2'-deoxyadenosine (2'-Br-dAdo)
EINECS	Contact for details

Quality Control

Our 2'-Bromo-2'-Deoxyadenosine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, meeting the exacting requirements of research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.