Description

2'-Amino-2'-Deoxycytidine-5'-Triphosphate (CAS NO 65444-12-4) is a modified nucleoside triphosphate analog, a critical building block for advanced molecular biology and biochemistry research. This compound is essential for applications requiring the site-specific incorporation of modified bases into nucleic acid chains. It is primarily utilized by researchers and developers in the fields of next-generation sequencing (NGS), polymerase chain reaction (PCR) probe development, and synthetic biology.

Application

• Next-Generation Sequencing (NGS): Used as a substrate for DNA polymerases in sequencing-by-synthesis platforms to introduce specific modifications or chain-terminating properties.
• PCR and qPCR Probe Development: Enables the synthesis of oligonucleotide probes with enhanced binding specificity or fluorescent labeling capabilities.
• Site-Directed Mutagenesis: Facilitates the precise introduction of mutations or modified bases into plasmids and genes for functional studies.
• Aptamer and SELEX Technology: Serves as a modified nucleotide for generating nucleic acid libraries with increased chemical diversity for selecting high-affinity binders.
• Structural Biology Studies: Incorporated into RNA or DNA to study nucleic acid-protein interactions and enzyme mechanisms.
• Diagnostic Assay Development: Key component in the manufacture of advanced diagnostic kits requiring stable, modified nucleic acid components.

Basic Information

Product Name	2'-Amino-2'-Deoxycytidine-5'-Triphosphate
CAS No.	65444-12-4
Molecular Formula	C9H16N5O13P3
Molecular Weight	503.17 g/mol
Synonyms	2'-Amino-2'-deoxy-CTP; 2'-NH2-dCTP; 2'-Amino-dCTP; 2'-Amino-2'-deoxycytidine triphosphate; Amino-modified dCTP; 2'-Amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate); dCTP-NH2; 2'-Amino-2'-deoxycytidine-5'-triphosphate, trisodium salt
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxycytidine-5'-Triphosphate is manufactured under stringent quality systems to ensure the high purity and consistency required for sensitive life science applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our production environment is designed to meet the exacting standards of research and diagnostic industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.