Description

5-(Propargyloxy)-2'-Deoxyuridine is a chemically modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. Its unique propargyloxy functional group makes it a versatile intermediate for click chemistry applications, enabling the synthesis of labeled probes and targeted drug conjugates. This compound is essential for researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug discovery, and diagnostic probe development.

Application

• Click Chemistry Reagent: Acts as a critical intermediate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create labeled nucleosides.
• Antiviral Research: Serves as a precursor in the synthesis of novel nucleoside analogs for evaluating antiviral activity against various viruses.
• Molecular Probe Synthesis: Used to fabricate fluorescent or biotin-labeled probes for nucleic acid detection and imaging studies.
• Bioconjugation: Enables the site-specific attachment of biomolecules, such as oligonucleotides or peptides, for targeted delivery systems.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in the development of new therapeutic agents.
• Academic & Industrial R&D: Employed in basic research to study enzyme mechanisms and DNA/RNA interactions.

Basic Information

Product Name	5-(Propargyloxy)-2'-Deoxyuridine
CAS No.	65367-85-3
Molecular Formula	C12H14N2O5
Molecular Weight	266.25 g/mol
Synonyms	5-Propargyloxy-2'-deoxyuridine; 5-(2-Propynyloxy)-2'-deoxyuridine; 2'-Deoxy-5-(2-propyn-1-yloxy)uridine; 5-O-Propargyl-2'-deoxyuridine; PdU (Propargyl-deoxyuridine); 5-(Prop-2-yn-1-yloxy)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-(Propargyloxy)-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.