Description

Guanosine, n-Acetyl-, 2',3'-Diacetate is a key protected nucleoside derivative, essential for advanced organic synthesis and pharmaceutical research. Its primary value lies in serving as a crucial synthetic intermediate, enabling the controlled construction of complex nucleotide analogs and oligonucleotides. This high-purity compound is particularly needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for developing novel therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research, diagnostics, and therapeutic applications (e.g., antisense, siRNA).
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor in studies of nucleoside-metabolizing enzymes.
• Prodrug Development: Serves as a protected precursor in the design of prodrugs to enhance the bioavailability and stability of active nucleoside agents.
• Chemical Biology Probes: Utilized to create labeled or tagged nucleotide derivatives for tracking and mechanistic studies within biological systems.
• Agrochemical Research: Acts as an intermediate in the development of new nucleotide-based pesticides or plant growth regulators.

Basic Information

Product Name	Guanosine, n-Acetyl-, 2',3'-Diacetate
CAS No.	65360-02-3
Molecular Formula	C₁₄H₁₇N₅O₇
Molecular Weight	367.32 g/mol
Synonyms	2',3'-Di-O-acetyl-N2-acetylguanosine; N2-Acetyl-2',3'-di-O-acetylguanosine; N2,2',3'-Triacetylguanosine; Guanosine, N-acetyl-, 2',3'-diacetate; 9-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(hydroxymethyl)oxolan-2-yl]-N-(acetylamino)-2-amino-1H-purin-6-one; Protected Guanosine Derivative; Acetylated Guanosine Intermediate
EINECS	Contact for details

Quality Control

Our Guanosine, n-Acetyl-, 2',3'-Diacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain product integrity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.