Description

2-Chloropyridine-4-Carbonyl Chloride is a highly reactive and versatile organic intermediate, essential for constructing complex molecular architectures. Its dual functionality as an acid chloride and a halogenated heterocycle makes it a critical building block for introducing the 2-chloropyridine-4-carbonyl moiety into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloropyridine scaffold is a common bioactive motif.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, polymers, and liquid crystals due to its rigid, aromatic structure.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloropyridine-4-Carbonyl Chloride
CAS No.	65287-34-5
Molecular Formula	C6H3Cl2NO
Molecular Weight	176.00 g/mol
Synonyms	4-(Chlorocarbonyl)-2-chloropyridine; 2-Chloroisonicotinoyl chloride; 2-Chloro-4-pyridinecarbonyl chloride; Isonicotinoyl chloride, 2-chloro-; 2-Chloropyridine-4-carboxylic acid chloride; 2-Chloro-4-carboxypyridine chloride; 4-Carboxy-2-chloropyridine chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloropyridine-4-Carbonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC), identity (by IR and NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.