Description

Nitrobenzylthioinosine 5'-Monophosphate is a chemically modified nucleotide analog of significant interest in biochemical and pharmacological research. This compound serves as a critical tool for investigating nucleoside transport mechanisms and enzyme inhibition, particularly targeting key pathways in cellular metabolism. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, virology, and metabolic disorder studies, where precise biochemical probes are essential.

Application

• Biochemical Research: Used as a potent and selective inhibitor of equilibrative nucleoside transporters (ENTs) to study nucleoside uptake and related cellular processes.
• Oncology Research: Investigated for its potential to modulate nucleoside analog efficacy, relevant in cancer chemotherapy studies.
• Enzyme Studies: Serves as a substrate analog for enzymes like 5'-nucleotidase and other phosphotransferases to elucidate reaction mechanisms.
• Virology Research: Applied in studies exploring the replication mechanisms of viruses that are dependent on host nucleoside metabolism.
• Metabolic Pathway Analysis: A key reagent for probing purine salvage pathways and nucleotide metabolism in various cell models.
• Pharmaceutical Development: Employed in early-stage drug discovery as a reference compound for developing novel nucleoside-based therapeutics.

Basic Information

Product Name	Nitrobenzylthioinosine 5'-Monophosphate
CAS No.	65199-10-2
Molecular Formula	C17H18N5O7PS
Molecular Weight	467.39 g/mol
Synonyms	NBMPR-MP; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine 5'-Monophosphate; S-(4-Nitrobenzyl)-6-thioinosine 5'-Monophosphate; Nitrobenzylmercaptopurine Ribonucleoside Monophosphate; 6-[(4-Nitrobenzyl)thio]inosine 5'-Monophosphate; ENT1 Inhibitor (phosphorylated form); 5'-NBTI-MP
EINECS	Contact for details

Quality Control

Our Nitrobenzylthioinosine 5'-Monophosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can provide material characterized by HPLC, NMR, and mass spectrometry upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.