Description

n-[3-[(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-Methyl-Amino]Propyl]Benz Amide Hydrochloride is a high-purity, synthetically derived quinazoline derivative, primarily utilized as a critical pharmaceutical intermediate. This compound matters because it serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), where consistent quality and reliable supply are paramount. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly in oncology and targeted therapy research.
• Chemical Synthesis Building Block: Used in organic synthesis for constructing quinazoline-based scaffolds with specific biological activity.
• Biochemical Research: Employed in laboratory settings for studying enzyme inhibition and signal transduction pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Utilized in the early-stage development and optimization of novel drug candidates.

Basic Information

Product Name	n-[3-[(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-Methyl-Amino]Propyl]Benz Amide Hydrochloride
CAS No.	65189-49-3
Molecular Formula	C21H26N6O3 · HCl
Molecular Weight	446.94 g/mol
Synonyms	4-Amino-6,7-dimethoxy-2-[[3-[(phenylcarbonyl)amino]propyl]methylamino]quinazoline hydrochloride; Benzamide, N-[3-[[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]]-, monohydrochloride; PD 153035 hydrochloride; ZD 1839 intermediate; Gefitinib intermediate derivative; EGFR-TK inhibitor intermediate; Quinazoline amine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our n-[3-[(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-Methyl-Amino]Propyl]Benz Amide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.