Description

Diphenyl 1-(Cbz-Amino)Isobutylphosphonate is a specialized organophosphorus compound designed as a key building block in advanced organic synthesis. This chemical matters for its role as a protected amino phosphonate reagent, enabling the precise introduction of phosphonate and amino functionalities into target molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of protease inhibitors, prodrugs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of peptide mimetics and enzyme inhibitors, particularly for antiviral and anticancer research.
• Prodrug Synthesis: Used to construct phosphonate-based prodrugs, which improve the bioavailability and targeting of active pharmaceutical ingredients.
• Peptide Chemistry: Serves as a protected phosphonamidate building block for the solid-phase and solution-phase synthesis of modified peptides.
• Chemical Biology Probes: Employed in the development of activity-based probes and molecular tools for studying enzyme function and signal transduction pathways.
• Agrochemical Research: Utilized as an intermediate in the design of novel herbicides and plant growth regulators with phosphonate motifs.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialized polymers and functional materials.

Basic Information

Product Name	Diphenyl 1-(Cbz-Amino)Isobutylphosphonate
CAS No.	65164-83-2
Molecular Formula	C24H26NO5P
Molecular Weight	439.44 g/mol
Synonyms	Diphenyl P-[(benzyloxycarbonyl)amino]-2-methylpropylphosphonate; (Cbz-Amino)isobutylphosphonic Acid Diphenyl Ester; 1-[(Benzyloxy)carbonyl]amino-2-methylpropylphosphonic Acid Diphenyl Ester; Z-Aib(PO(OPh)2)-OH; N-Cbz-2-amino-3-methylbutylphosphonic Acid Diphenyl Ester; (1-((Benzyloxy)carbonylamino)-2-methylpropyl)phosphonic Acid Diphenyl Ester; CBZ-AIBU(PO(OPh)2)
EINECS	Contact for details

Quality Control

Our Diphenyl 1-(Cbz-Amino)Isobutylphosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.