Description

Guanosine 5'-Monophosphate Methyl Ester is a chemically modified nucleotide derivative where the phosphate group of guanosine monophosphate is esterified with a methyl group. This modification is crucial for enhancing the molecule's stability and altering its biochemical properties, making it a valuable synthetic intermediate and research tool. It is primarily sought after by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in oligonucleotide synthesis, biochemical studies, and as a precursor for more complex nucleotide analogs.

Application

• Oligonucleotide Synthesis: Serves as a key building block (phosphoramidite precursor) in the solid-phase synthesis of DNA and RNA sequences for research, diagnostics, and therapeutic development.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of kinases, phosphatases, and other nucleotide-processing enzymes.
• Pharmaceutical Intermediates: Acts as a critical synthetic precursor in the development of novel antiviral and anticancer nucleotide-based prodrugs.
• Molecular Biology Reagents: Incorporated into the formulation of specialized buffers and kits for molecular cloning, PCR, and other nucleic acid amplification techniques.
• Labeled Compound Synthesis: Utilized as a starting material for the synthesis of radioisotope or fluorescently labeled guanosine derivatives for tracking and imaging studies.
• Enzyme Mechanism Probes: Employed to study transition state analogs in enzymatic reactions involving phosphate transfer, aiding in drug discovery.

Basic Information

Product Name	Guanosine 5'-Monophosphate Methyl Ester
CAS No.	65128-55-4
Molecular Formula	C11H15N5O7P
Molecular Weight	360.24 g/mol
Synonyms	5'-GMP Methyl Ester; Guanosine 5'-(methyl phosphate); Methyl guanosine 5'-monophosphate; Guanosine 5'-monophosphate, methyl ester; GMP Methyl Ester; 5'-O-Phosphonomethylguanosine; Guanosine 5'-(dihydrogen phosphate) methyl ester
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Monophosphate Methyl Ester is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.