Description

n-(n-(4-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)Glycyl)-L-Glu Tamic Acid is a high-purity, complex folate derivative with significant biochemical relevance. This compound is valued for its role as a key intermediate and reference standard in advanced pharmaceutical research and development. It is primarily sought by manufacturers and research institutions in the pharmaceutical, biotechnology, and life science sectors for applications in metabolic studies, enzyme inhibition assays, and the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antifolate drugs and targeted cancer therapeutics.
• Biochemical Research: Used as a high-purity reference standard in enzyme kinetics studies, particularly for dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Metabolic Pathway Analysis: Employed in cell culture and in vitro studies to investigate folate metabolism and one-carbon transfer processes.
• Diagnostic Reagent Development: Serves as a key component in the development of diagnostic assays and kits for measuring folate levels or related enzymatic activity.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research in biochemistry and molecular biology.

Basic Information

Product Name	n-(n-(4-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)Glycyl)-L-Glu Tamic Acid
CAS No.	65118-36-7
Molecular Formula	C₂₀H₂₃N₉O₆
Molecular Weight	485.46 g/mol
Synonyms	4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl-L-glutamylglycine; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamylglycine; Folate Derivative 65118-36-7; Pteroic acid glutamylglycine derivative; N-(p-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl)-L-glutamylglycine; L-Glutamic acid, N-[N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]glycyl]-; Glycine, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-glutamyl derivative
EINECS	Contact for details

Quality Control

Our n-(n-(4-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)Glycyl)-L-Glu Tamic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.