Description

Urapidil Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) used in the synthesis of antihypertensive medications. Its primary value lies in its role as a potent α-1 adrenergic receptor antagonist, which is critical for developing effective vasodilatory drugs. This compound is essential for pharmaceutical manufacturers and research institutions focused on cardiovascular drug development and production. We supply this material with a commitment to stringent quality control and reliable global supply chain logistics.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in finished dosage forms for hypertension treatment.
• Cardiovascular Research: Critical reagent in preclinical and clinical research studies investigating α-adrenergic blockade and blood pressure regulation.
• Reference Standard: Serves as a certified reference material (CRM) for quality control laboratories performing HPLC, LC-MS, or NMR analysis of drug products.
• Process Development: Used in scaling up and optimizing synthetic routes for antihypertensive drugs in pilot plants and commercial manufacturing.
• Formulation Studies: Employed in the development of various drug delivery systems, including tablets, capsules, and injectables.
• Generic Drug Manufacturing: A key starting material (KSM) or intermediate for producers of generic urapidil-based medications.

Basic Information

Product Name	Urapidil Hydrochloride
CAS No.	64887-14-5
Molecular Formula	C20H29N5O3 • HCl
Molecular Weight	423.94 g/mol
Synonyms	6-({3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride; Ebrantil; Urapidil HCl; 1-(2-Methoxyphenyl)-4-[3-[(6-methyl-2,4-dioxo-1,3(2H,4H)-pyrimidinylidene)amino]propyl]piperazine hydrochloride; Urapidilium Chloride; BAY 1011; BAY-a-1041
EINECS	Contact for details

Quality Control

Our Urapidil Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical applications. We provide full traceability and Certificates of Analysis (COA) that detail purity, identity, and impurity profiles. Our quality commitment aligns with ICH guidelines and relevant pharmacopeial standards (e.g., USP, EP) for APIs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.