Description

Butoconazole Nitrate CAS NO 64872-77-1 is a synthetic imidazole derivative widely recognized for its potent antifungal activity. This compound is a critical active pharmaceutical ingredient (API) essential for formulating effective topical treatments. It is primarily required by pharmaceutical manufacturers and research institutions developing antifungal medications for human and veterinary use.

Application

• Primary use as the active pharmaceutical ingredient (API) in topical antifungal creams, ointments, and suppositories.
• Formulation of prescription and over-the-counter (OTC) medications for the treatment of vulvovaginal candidiasis (yeast infections).
• Research and development of novel antifungal agents and combination therapies in pharmaceutical R&D.
• Manufacturing of veterinary antifungal products for topical application.
• Use as a reference standard in analytical laboratories for quality control and method development.
• Investigation in academic and clinical research studies on antifungal mechanisms and resistance.

Basic Information

Product Name	Butoconazole Nitrate
CAS No.	64872-77-1
Molecular Formula	C19H15Cl3N2O·HNO3
Molecular Weight	474.70 g/mol
Synonyms	Butoconazole Nitrate; 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole nitrate; RS-35887; Femstat (brand name); Butoconazolum Nitricum; (±)-Butoconazole Nitrate
EINECS	Contact for details

Quality Control

Our Butoconazole Nitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets Ph. Eur./USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.