Description

Methotrexate-γ-Monoamide is a key chemical intermediate and derivative of the well-known pharmaceutical agent methotrexate. This compound matters for its role in advanced pharmaceutical research and development, particularly in the synthesis of novel drug conjugates and targeted therapies. It is primarily needed by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in oncology and immunology research.

Application

• Pharmaceutical intermediate for the synthesis of novel methotrexate analogs and prodrugs.
• Key building block in research for targeted cancer therapies and antibody-drug conjugates (ADCs).
• Biochemical research tool for studying folate metabolism and enzyme inhibition mechanisms.
• Reference standard in analytical laboratories for quality control and method development.
• Starting material for the preparation of specialized diagnostic agents and research chemicals.

Basic Information

Product Name	Methotrexate-γ-Monoamide
CAS No.	64801-56-5
Molecular Formula	C₂₀H₂₂N₈O₅
Molecular Weight	454.44 g/mol
Synonyms	N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid γ-amide; L-Glutamine, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; Methotrexate γ-amide; MTX-γ-Amide; MTX-GA; Methotrexate amide; 4-Amino-10-methylfolic acid amide
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-Monoamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.