Description

N4 2'-o-Dibutyrylcytidine 3':5'-Cyclic CAS NO 64649-87-2 is a chemically modified nucleoside derivative, specifically a dibutyrylated analog of cyclic cytidine monophosphate (cCMP). This compound is a crucial biochemical tool and a key intermediate in pharmaceutical research, valued for its enhanced cell membrane permeability compared to its parent nucleotide. It is primarily utilized by research institutions and pharmaceutical developers focused on cell signaling pathways, nucleotide metabolism, and the development of novel therapeutic agents targeting intracellular processes.

Application

• Biochemical Research: Used as a cell-permeable analog of cyclic cytidine monophosphate (cCMP) to study intracellular signaling cascades and nucleotide-mediated regulatory mechanisms.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of more complex nucleotide-based drugs and prodrugs.
• Cell Biology Studies: Employed to investigate the role of cyclic nucleotides in cellular processes such as differentiation, proliferation, and apoptosis.
• Enzyme Substrate/Analog: Acts as a substrate or inhibitor for enzymes like phosphodiesterases and protein kinases in mechanistic studies.
• Prodrug Development: The dibutyryl moiety enhances lipophilicity, making it a model compound for designing prodrug strategies to improve drug delivery.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	N4 2'-o-Dibutyrylcytidine 3':5'-Cyclic
CAS No.	64649-87-2
Molecular Formula	C22H32N3O8P
Molecular Weight	497.48 g/mol
Synonyms	2'-O-Dibutyryl-cCMP; N4,2'-O-Dibutyrylcytidine 3',5'-cyclic monophosphate; Dibutyryl cyclic CMP; DB-cCMP; cCMP dibutyrate; Cyclic cytidine 3',5'-monophosphate N4,2'-O-dibutyrate; 2'-O-Dibutyrylcytidine cyclic 3',5'-(hydrogen phosphate); N4,2'-Di-O-butyrylcytidine 3',5'-cyclic phosphate
EINECS	Contact for details

Quality Control

Our N4 2'-o-Dibutyrylcytidine 3':5'-Cyclic is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.