Description

5-Carboxycytidine is a modified nucleoside derivative of cytidine, featuring a carboxylic acid functional group at the 5-position of the cytosine base. This structural modification makes it a valuable intermediate and building block in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, medicinal chemistry, and proteomics.

Application

• Biochemical Research: Used as a key intermediate in the synthesis of modified oligonucleotides and nucleoside analogs for studying RNA structure, function, and metabolism.
• Pharmaceutical Development: Serves as a precursor in the creation of novel therapeutic agents, including potential antivirals and anticancer drugs targeting nucleic acid pathways.
• Proteomics & Epitranscriptomics: Acts as a critical reagent in the study of post-transcriptional RNA modifications and their role in cellular regulation and disease.
• Diagnostic Reagent Synthesis: Employed in the development of specialized probes and labeled compounds for diagnostic assays and imaging techniques.
• Academic & Industrial R&D: Essential for fundamental research in chemistry and biology laboratories exploring nucleotide chemistry and drug discovery.

Basic Information

Product Name	5-Carboxycytidine
CAS No.	64623-37-6
Molecular Formula	C10H13N3O7
Molecular Weight	287.23 g/mol
Synonyms	5-Carboxycytidine; 5-Carboxy-Cytidine; Cytidine-5-carboxylic acid; 1-β-D-Ribofuranosyl-5-carboxycytosine; 5-Carboxy-1-β-D-ribofuranosylcytosine; 5-Carboxy-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Carboxycytidine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.