Description

2-(1,3-Dioxoisoindol-2-Yl)-3-Methyl-Butanoyl Chloride is a specialized organic intermediate featuring a reactive acid chloride group and a phthalimide-protected amine moiety. This compound matters for its role as a key building block in the synthesis of complex molecules, enabling the controlled introduction of specific functional groups. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly those requiring a protected amino acid derivative.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where its specific structure contributes to biological activity.
• Peptide Mimetic Research: Serves as a building block for creating peptide analogs and conformationally restricted scaffolds in medicinal chemistry.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent for synthesizing specialty polymers with tailored properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and labeled compounds for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical manufacturers offering bespoke synthesis services to clients.

Basic Information

Product Name	2-(1,3-Dioxoisoindol-2-Yl)-3-Methyl-Butanoyl Chloride
CAS No.	64404-11-1
Molecular Formula	C13H12ClNO3
Molecular Weight	265.69 g/mol
Synonyms	2-(1,3-Dioxoisoindolin-2-yl)-3-methylbutanoyl chloride; 3-Methyl-2-(1,3-dioxoisoindol-2-yl)butanoyl chloride; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanoyl chloride; N-(1,3-Dioxoisoindolin-2-yl)-3-methylbutanoyl chloride; Valine-derived phthalimide acid chloride; Isobutylphthalimide acetyl chloride derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of 2-(1,3-Dioxoisoindol-2-Yl)-3-Methyl-Butanoyl Chloride adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot undergoes comprehensive analytical characterization, including purity assay and identification of key impurities. Certificates of Analysis (COA) detailing all test results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.