Description

trans-3-(Trifluoromethyl)Cinnamoyl Chloride is a high-value, reactive organic intermediate characterized by its cinnamoyl chloride backbone and a strategically positioned trifluoromethyl group. This compound matters for its role as a versatile building block in the synthesis of more complex molecules, where it introduces both the cinnamic acid derivative framework and the highly sought-after fluorine moiety. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, altering surface properties, chemical resistance, and durability.
• Chemical Research & Development: A crucial reagent for academic and industrial research exploring new fluorinated organic molecules and their properties.
• Peptide Mimetics & Bioconjugation: The acid chloride functionality allows for efficient amide bond formation in the synthesis of peptide analogs and bioconjugates.

Basic Information

Product Name	trans-3-(Trifluoromethyl)Cinnamoyl Chloride
CAS No.	64379-91-5
Molecular Formula	C10H6ClF3O
Molecular Weight	234.60 g/mol
Synonyms	(E)-3-[3-(Trifluoromethyl)phenyl]prop-2-enoyl chloride; 3-(Trifluoromethyl)cinnamoyl chloride; (E)-3-(3-Trifluoromethylphenyl)acryloyl chloride; trans-3-(Trifluoromethyl)phenylacryloyl chloride; (2E)-3-[3-(Trifluoromethyl)phenyl]prop-2-enoyl chloride; 3-(Trifluoromethyl)trans-cinnamoyl chloride; α,β-Unsaturated acid chloride of 3-(trifluoromethyl)cinnamic acid
EINECS	Contact for details

Quality Control

Our trans-3-(Trifluoromethyl)Cinnamoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of cGMP and ISO 9001 standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.