Description

(+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride CAS NO 64312-89-6 is a versatile chiral derivatizing agent and a key building block in advanced organic synthesis. Its core value lies in its trifluoromethyl and methoxy-substituted phenylacetyl chloride structure, which is instrumental for introducing chiral centers and fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Chiral Derivatizing Agent: Used for the resolution of racemic mixtures of alcohols and amines via diastereomeric ester or amide formation for analytical purposes.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, particularly those requiring chiral, fluorinated aromatic components.
• Agrochemical Synthesis: Employed in the production of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized chiral ligands used in asymmetric catalysis.
• Material Science Research: Utilized in the development of novel fluorinated polymers and advanced organic materials with unique properties.
• Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical production.

Basic Information

Product Name	(+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride
CAS No.	64312-89-6
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride; MTPA-Cl; Mosher's acid chloride; (±)-MTPA chloride; 2-Methoxy-2-(trifluoromethyl)-2-phenylacetyl chloride; 2-Methoxy-2-(trifluoromethyl)phenacetyl chloride; α-Methoxy-α-trifluoromethylphenylacetic acid chloride; DL-MTPA-Cl
EINECS	Contact for details

Quality Control

Our (+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.