Description

Adenosine,3",5'-Bis-o-(Tetrahydro-2H-Pyran-2-Yl)-,2'-Acetate is a key protected nucleoside derivative, specifically designed for advanced organic synthesis and pharmaceutical research. This compound is crucial for its role as a sophisticated building block in the synthesis of modified oligonucleotides and nucleotide analogs, where selective protection of hydroxyl groups is required. It is primarily utilized by research institutions and pharmaceutical development teams working on novel therapeutics, diagnostic probes, and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel adenosine receptor agonists/antagonists and other nucleoside-based active pharmaceutical ingredients (APIs).
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and signaling pathways.
• Prodrug Development: Employed in the design of prodrugs to enhance the bioavailability and stability of nucleoside analogs.
• Labeled Compound Synthesis: A starting material for introducing radiolabels (e.g., tritium, carbon-14) or fluorescent tags into nucleoside structures for tracing and imaging studies.
• Academic & Industrial R&D: Essential for chemical biology research and the development of new molecular entities in biotechnology and medicinal chemistry.

Basic Information

Product Name	Adenosine,3",5'-Bis-o-(Tetrahydro-2H-Pyran-2-Yl)-,2'-Acetate
CAS No.	64183-28-4
Molecular Formula	C22H32N5O8
Molecular Weight	494.52 g/mol
Synonyms	2'-O-Acetyl-3',5'-bis-O-(tetrahydro-2H-pyran-2-yl)adenosine; 2'-Acetyl-3',5'-bis-O-(tetrahydro-2-pyranyl)adenosine; 3',5'-Di-O-(tetrahydro-2H-pyran-2-yl)-2'-O-acetyladenosine; N6-Adenosine, 2'-acetate, 3',5'-bis-O-(tetrahydro-2H-pyran-2-yl)-; THP-protected Adenosine-2'-acetate; Protected Adenosine Derivative
EINECS	Contact for details

Quality Control

Our Adenosine,3",5'-Bis-o-(Tetrahydro-2H-Pyran-2-Yl)-,2'-Acetate is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping the product under an inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.